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Martin Jones to start Sharks’ do-or-die Game 5 vs. Golden Knights

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first_imgSAN JOSE — Martin Jones will be the Sharks’ starting goaltender against the Vegas Golden Knights on Thursday in a do-or-die Game 5, which could see the return of defenseman Marc-Edouard Vlasic.Like our Sharks Facebook page for more San Jose Sharks news, commentary and conversation.Vlasic, skating for the first time since he suffered an undisclosed injury in Game 2 last Friday, felt good after he was a full participant in Wednesday’s practice and is a possibility to play if he responds well, …last_img

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Australian international fares down 8pc in 2016

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first_imgInternational airfares to and from Australia fell by about 8 per cent in real terms in 2016 but an airline industry group has warned rising fees could endanger the bonanza.The Board of Airline Representatives of Australia, which represents 32 international airlines, said real airfares to and from Australia had fallen by almost 40 per cent since 2006.“in 1994, an economy flight from Sydney to Singapore cost about $A2300 in today’s terms,’’ the group said. “Now the same flight ranges from $A320 to $A720.’’Drawing on data from the International Air Transport Association and sources such as the Australian Bureau of Statistics, BARA found overseas visitor trips had grown by 2.4 million over 11 years while the number of overseas trips taken by Australians had grown by 4.9 million over the same period.It said the growth in passenger volumes to and from Australia had benefited from the sustained reduction in real international airfares as well as income growth.Real average air fares had dropped by 38 per cent for Australians heading outbound and 34 per cent for overseas visitors to the country, the group’s analysis found.Airfares are largely affected by the amount of capacity and competition in a market, including the presence of low-cost carriers, but many airlines have also worked hard to improve productivity in recent years.BARA executive director Barry Abrams said competition ensured that productivity improvements at airlines were passed through to passengers but he warned the industry could not keep cutting airfares indefinitely, particularly in an environment where other aviation fees were increasing.An annual report by the Australian Competition and  Consumer Commission recently found that  Australia’s biggest airports were recovering substantially more aeronautical revenue per passenger than a decade ago as they moved to offset increased costs per passenger and grow profit margins.The ACCC estimated that over the past decade, the nation’s four biggest airports had collected $A1.57 billion more in revenue from airlines than they would otherwise have collected if average prices were held constant in real terms.   “Infrastructure charges and everything else can’t keep going up if you want to maintain airfare affordability and support that downward trend that we have,’’  Abrams told AirlineRatings.“With the continual modernisation of aircraft and the efficiency of flight and these sorts of initiatives, there’s still an underlying productivity trend within the airlines.“The question then is will the fees and the charges and the increases from everybody else going to start overwhelming that efficiency trend.’’International airfares to and from Australia fell by about 8 per cent in real terms in 2016, according to an airline industry group.last_img read more

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Christmas caring packed in a shoebox

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first_img22 December 2010Thanks to an innovative community project, some of South Africa’s underprivileged children will be able to experience the joy of Christmas.In a heart-warming display of the festive season spirit of caring and sharing, a plethora of presents and a whole lot of love have been carefully packed into shoeboxes to provide almost 32 000 needy children with a gift this Christmas.The Santa Shoebox Project was established in Cape Town in 2006 by Dee Boehner, director of the public benefit organisation then known as From the Children, To the Children.The organisation has since changed its name to the Kidz2Kidz Trust, but its principle of providing privileged children with an opportunity to do something for their not-so-fortunate peers, thereby teaching them the importance and the joy of giving, remains the same.The project’s first outing five Christmases ago saw 180 personalised gift boxes pledged, packed and delivered for distribution to needy youngsters. The following year’s total reflected a strong growth to 2 000 boxes, which burgeoned to more than 8 000 in 2008.Last year’s donations grew even more to see Santa’s bags at collection points around the country stuffed with more than 16 000 beautifully decorated shoeboxes, which were distributed to more than 200 children’s homes, childcare facilities and places of safety.The target for 2010 was initially set at 16 000 boxes, but strong support saw this figure revised upwards to 28 000.In a thrilling indication of how the project has captured the imagination of a caring nation, a phenomenal 31 663 boxes were eventually pledged and have been dropped off at the 15 collection points around the country.This year, for the first time, the project is also extending into neighbouring Namibia, with a collection point in Windhoek.Spreading the spiritOne of those who took part this year for the first time was Lauren Collier of Port Elizabeth. She heard of the initiative from friends in Cape Town who had previously supported it.While Collier was wondering how she would be able to get her box to one of the drop-off points in the Mother City, she learnt that the project was coming to Port Elizabeth this year for the first time thanks to the initiative of local co-ordinator Kim Keen. After also learning of the venture while on a visit to Cape Town, Keen was determined to see it implemented in her home city.And the response has “completely blown me away”, she says.She started her planning with a very conservative and, she hoped, reachable target of 150 boxes. Within a week of online pledges opening nationally on 1 September, all of these Port Elizabeth boxes had been snapped up and Keen was inundated with calls from would-be donors eager to deliver.As word of the project spread rapidly, local pledges kept pouring in until there were 1 125 boxes, enabling Keen to increase the initial list of four beneficiary facilities in Port Elizabeth to 18. Supporters even drove in from the neighbouring centres of Grahamstown and Port Alfred, more than 100km away, to drop off their boxes, she says.But it did not end there. East London, some 300km further up the Eastern Cape coast, got wind of the project and collected 60 boxes for its needy children – despite having no official co-ordinator. Keen roped her mother, a Buffalo City resident, in to help. “She didn’t know what had hit her,” she laughs.Another Eastern Cape town, the surfing mecca of Jeffreys Bay, collected 70 boxes, while a supporter from George, on the Garden Route, approached Keen to volunteer as co-ordinator for next year, to see the project also implemented there.An easy way to contributeBut what is it about this particular project that has caused an interested South African public to so generously open their hearts, and their wallets, for the country’s children?“I always like to do something for those less fortunate at Christmas, and this seemed an ideal way to contribute,” says 23-year-old Collier, who has just completed her studies as a primary school teacher.What especially appealed to her were the very clear guidelines for packing a box, which she found on the project’s website“This makes it so much easier than trying to figure out what is appropriate to give – and all the children at any one facility then get more or less the same sort of things, making sure no one is disappointed when they open their box.”Another aspect that appealed to Collier was the personalised gift-giving. Project supporters can select the age and gender of the child (or children) for whom the box is intended, and receive a gift label with the child’s name to be attached to it. They also know the organisation through which the child will be reached.Keen agrees that this is one of the project’s most appealing aspects – that supporters can know exactly where their donations will be going and who will benefit. However, generic boxes are accepted when the number of boxes donated exceeds the number of children whose names have been provided by the beneficiary organisations.The project, on its website, explains that many people want to contribute to their community or do their bit for charity, but often do not know where to start.“The Santa Shoebox Project takes pride in channelling all that positive energy and goodwill into something that is credible, achievable, makes a real difference in a specific child’s life and leaves the donors feeling really good about themselves,” it says.Gift guidelinesThe website indicates a list of items that must be packed into each box – and those to be avoided. Boxes are required to contain a toothbrush and toothpaste, soap and a facecloth, an item of clothing, educational supplies, sweets and a toy. This carefully thought-out list ensures the child gets something to use, to wear, to do, to eat and to love.Gift ideas for each category are provided, with further ideas for boxes for babies and teenagers. All gifts must be new and age-appropriate. The organisation also warns of items which should not be packed into the box, such as fragile objects, electronics, medicines or violence-related toys such as guns or soldiers.Creativity is encouraged in both gift selection and decorating of the boxes, which can then become special keepsake boxes for the children – many of whom might never previously have had anything they could claim as exclusively their own.Volunteers at the designated drop-off points receive the boxes for distribution – this year to about 350 child-care facilities throughout the country, usually at Joy of Giving celebration parties.And Keen found plenty of local businesses only too happy to come to the party this year – all of Port Elizabeth’s celebration events have been sponsored by local companies, further enhancing the children’s Christmas experience.For her, being involved in “this amazing project” has been a humbling experience, Keen says. “It has been absolutely fantastic to realise how many genuine, caring and wonderful people filled with humanity there are out there.”And she has indeed seen the joy that both giving and receiving can bring. “Parents have really encouraged their children to get involved and make this project their own,” she says. “So youngsters have arrived beaming and proudly bearing their boxes – to be given to ‘a little boy’ or ‘a little girl … just like me’.”And the excitement and joy that opening a box holds for the receiver are something to behold, she says. “We had one young boy of about 10 who nearly went into orbit with delight when he unpacked his box to find a really cool Ben 10 t-shirt inside.”So, while it might not yet be the night before Christmas, Santa’s ever-growing band of helpers is already out there, hard at work delivering the goods.First published by MediaClubSouthAfrica.com – get free high-resolution photos and professional feature articles from Brand South Africa’s media service.last_img read more

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South African producer premieres new film at Venice festival

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first_img7 September 2015Anant Singh, the South African film producer, has teamed up with Canadian producer Robert Lantos, famous for his collaborations with auteur David Cronenberg, to produce a new film by acclaimed art house director Atom Egoyan.Remember is a contemporary drama about revenge and road trips, featuring an impressive cast of Hollywood legends and popular character actors. The film will be officially entered for competition at the Venice International Film Festival this month, as well as the Toronto Film Festival. Following the festivals, it will released on the North American art house circuit and later internationally, including an early 2016 release in South Africa.The film features a remarkable lead performance by Christopher Plummer (The Sound of Music and the Oscar winning Beginners) with an incredible supporting cast that includes fellow Oscar winner Martin Landau (Ed Wood), Swiss actor Bruno Ganz (Downfall) and Dean Norris from TV’s Breaking Bad.It tells the story of Zev (Plummer) as he discovers the Nazi guard who murdered his family during World War 2, living in the US under an assumed identity. Determined to find the man and deliver due justice, Zev must embark on a momentous cross-continent road-trip filled with interesting characters and surprising consequences.Singh says the performances by Plummer and Landau are what make the film so extraordinary, “coupled with the thrillingly dramatic storyline, (Remember) is a gripping film. (and we, the producers of the film) are confident that this will make the film a serious awards contender”.Director Egoyan, whose oeuvre explores themes of alienation and isolation in idiosyncratic but convincing tones, gained praise and recognition for his film The Sweet Hereafter in 1997. He went on to helm an impressive collection of modern cult and art house classics.Lantos has produced some of Canada’s biggest films, including Cronenberg’s Eastern Promises and eXistenZ, as well as 2010’s festival favourite Barney’s Version, starring Paul Giamatti and Dustin Hoffman.Singh is best known in South Africa for his ground-breaking work for the local film industry over the last 25 years. He was behind such box-office hits as Leon Schuster’s Mr Bones movies – South Africa’s highest grossing South African film series of all time – as well as critically acclaimed and award-winning showcases of South African stories, including Yesterday, Sarafina, Cry the Beloved Country and Long Walk To Freedom, starring Idris Elba as Nelson Mandela.His production company, Videovision Entertainment, is one of the leading media and entertainment bodies in Africa. With Videovision, Singh was instrumental in setting up Cape Town Film Studios in 2010. Offering state-of-the art equipment and technology, as well as over 60 hectares of film studios and associated facilities, Cape Town Film Studios has helped South Africa become a leading shooting location for local and international productions, including this year’s Mad Max: Fury Road.This is the first time Lantos and Singh have worked together on a production, despite being long-time contemporaries. Remember offers the opportunity for the two seasoned film business magnates to use their skills and knowledge to not only finance and market the film, but also to help find its direction. “It is wonderful to have a South African-Canadian collaboration on a project as illustrious as this. It is highly exciting for us (in light of the film being selected for) two of the world’s most prestigious film festivals,” Singh says.And for South African film, this is not the only project getting lots of international festival buzz in 2015. Also screening for competition in Venice is Endless River, by award-winning director Oliver Hermanus (Skoonheid and Shirley Adams).A 20-strong delegation of emerging filmmakers accompanied by Trade and Industry Deputy Minister Mzandile Masina will visit the Toronto Film Festival this year. The group intends to give the South African film industry more exposure on a world stage and network with some of the biggest names in film.SAinfo reporterlast_img read more

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Dimples Wig Hair Care Hairspray – 200ml : Firm hold but leaves wigs shinny.

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first_imgFirm hold but leaves wigs shinny. . Good product, does not feel hard. Gave a wonderful shine to all my wigs, and brushed out well. Left no build up of spray after using a few times before washing wig. Gave a good natural looking hold.Dimples Wig Hair Care Hairspray – 200mlGives desired shine and hold without stiffnessRecommended as the best brand for the use on wigs and hairpiecesEasy brush-out water soluble formulationDelicate scent that is not too strong with Anti Static formulationComes random in a white or black coloured bottle. As stated, arrived on time, pleased with product. Does the job and you dont even need to use it every day. For the last couple of years & it’s really good & brushes out easily. I’ve used for the last couple of years & it’s really good & brushes out easily x. Dimples Wig Hair Care Hairspray – 200ml : Firm hold but leaves wigs shinny. . Good product, does not feel hard. Gave a wonderful shine to all my wigs, and brushed out well. Does the job and you dont even need to use it every day. As stated, arrived on time, pleased with product. Have been using this product for a long time. Good hold, but brushes out easily. For the last couple of years & it’s really good & brushes out easily. I’ve used for the last couple of years & it’s really good & brushes out easily x. Have been using this product for a long time. Good hold, but brushes out easily. A have to product for artificial wigs regular hairspray ruins them. Does what it says on the tin and happy to recommend. . Does what it says on the tin and happy to recommend. A have to product for artificial wigs regular hairspray ruins them. Does what it says on the tin and happy to recommend. . Does what it says on the tin and happy to recommend. SummaryReviewer Nathalie DuboisReview Date2017-11-12 10:56:42Reviewed Item Dimples Wig Hair Care Hairspray – 200mlRating 4.0 / 5  stars, based on  15  reviewsPrice£8.99last_img read more

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Renu Bala gives India first gold in weightlifting

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first_imgRenu Bala Chanu gave India its first gold medal in Commonwealth Games weightlifting event after finishing on top in women’s 58-kg category in New Delhi at the Jawaharlal Nehru Stadium sports complex on Wednesday.Renu Bala outshone all her competitors as she smoothly lifted all the weights before failing in her last attempt of 103 kgs in clean and jerk event, but by then she had already pocketed the No. 1 position.And although Sean Lee of Australia tried to come close to her but she had to be satisfied with a silver medal, while Zoe Smith of England took bronze.Renu Bala looked comfortable from the very beginning. She ended the snatch event with a highest lift of 90 kgs that made her set a new Commonwealth Games record.Ciana Agricole with 87 kgs after the snatch event was placed second but she ultimately finished fourth.Then in the clean and jerk category, Renu Bala lifted 104 kgs in her very first attempt, and followed it up by 107 kgs to make it a total of 197.Lee, who with her successful lift of 106 in her second attempt in clean and jerk plus her 86 kgs lift in snatch event, acquired a total of 192.In her final lift, she opted for 111 kgs to pose some challenge to India but she failed. And that automatically handed Renu Bala the yellow medal.Renu Bala, on her part made an attempt to lift 113 kgs in her third and the final chance but she could not.The bronze medallist Zoe Smith, meanwhile ended with a total of 188 kgs.advertisementlast_img read more

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11 days agoAston Villa defender Mings defiant after England debut

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first_imgAbout the authorFreddie TaylorShare the loveHave your say Aston Villa defender Mings defiant after England debutby Freddie Taylor11 days agoSend to a friendShare the loveTyrone Mings was delighted to make his England debut despite being subjected to racist abuse.The Aston Villa stopper started alongside Harry Maguire at centre-back in the 6-0 win over Bulgaria.Mings was the victim of racist taunts from the home crowd, but he was happy the Three Lions finished the match.Speaking after the game, he said: “It was a great occasion; I made my England debut. Slightly overshadowed by a few disappointing chants, which could be clearly heard on the pitch, but we showed a great response and ultimately we let the football do the talking.”I think the protocol was effective, and there was less chanting after that. We made a decision at half-time to come out and play the game, which we thought was the right thing to do.” last_img read more

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Oklahoma State Honoring Members Of Basketball Program Who Died In Plane Crash 14 Years Ago Today

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first_imgOklahoma State honors 2001 plane crash victims.On January 27th, 2001, the Oklahoma State basketball program suffered an unthinkable tragedy when eight members of its family (two players and six staffers and broadcasters) died in a plane crash while returning from a game in Colorado. In the years since that traumatic event, the 10 people who died in the crash –including the pilot and co-pilot–have been memorialized with a banner hanging in the rafters of OSU’s home court, Gallagher-Iba Arena, and a memorial located inside the Athletics Center. Also, each year, at the home game closest to the date of the crash, Oklahoma State honors the 10. This post from the Cowboys’ official athletics Instagram account has all the details on the ceremony before tonight’s game against Baylor: Very touching and appropriate tribute for those whose lives were inexplicably cut short, and it’s incredible to think 14 years has passed since this tragedy happened.last_img read more

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Thalamus controls development of normal sleep and waking states study finds

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first_imgReviewed by James Ives, M.Psych. (Editor)Oct 12 2018Consciousness requires continuous, internally generated activity in the brain. The modulation of this activity is the basis of the electroencephalogram (EEG) and of generation of sleep, dreams, and perception. Achieving such activity is thus an important milestone in normal brain maturation, which occurs around birth. Successful transition to this activity indicates a good prognosis for babies born prematurely and/or suffering from damage to the brain.To be functional as a dreaming, seeing, and thinking entity the brain need to achieve two milestones: continuity, which means that the brain is always active and state dependence, meaning brain activity is modulated by sleep, waking, and attention. The circuit mechanisms behind the development of continuity and state dependence in the brain have remained unknown, but have been widely assumed to be located in the cerebral cortex, the convoluted brain structure responsible for thought and perception.A team from the George Washington University (GW) has published a study in the Journal of Neuroscience suggesting instead that the thalamus, a tiny nucleus deep in the brain, actually controls the development of state dependence and continuity.”Our results indicate that cellular changes in the thalamus relay function may be critical drivers for the maturation of background activity,” Matthew Colonnese, PhD, associate professor of pharmacology and physiology at the GW School of Medicine and Health Sciences, said. “Humans undergo developmental transitions in brain activity before and near birth.”Related StoriesResearch team to create new technology for tackling concussionMercy Medical Center adds O-arm imaging system to improve spinal surgery resultsStudy provides new insight into longitudinal decline in brain network integrity associated with agingDrawing on previous work by Colonnese, his team used advanced techniques to record simultaneously from multiple brain regions to pinpoint the circuit change responsible for the acquisition of continuity and state dependence measured in the sensory cortex. They were surprised to learn that activity changes in the thalamus, rather than the local cortical circuitry or the interconnectivity of two structures, can explain most of these critical developmental milestones.”From a clinical perspective, certain things can go wrong in birth, like hypoxic-ischemic encephalopathy, brain injury caused by lack of oxygen to the brain, and the brain can revert to a state of discontinuity or never develop continuity,” said Colonnese. “These findings could help us understand the circuit basis of human EEG development to improve diagnosis and treatment of infants in vulnerable situations. By putting the development of the EEG on a mechanistic basis we hope to increase its utility in the clinic.”Colonnese and his team, which includes Yasunobu Murata, PhD, a research scientist in Colonnese’s lab at GW and co-author of the study, are working to develop a comprehensive atlas of EEG patterns and brain lesions that cause them to aid in this process.Now that they have established the thalamus is in control, he said, the next step is to further define what circuit changes occur in brain development so clinicians can pinpoint from an EEG what’s gone wrong in cases like hypoxic-ischemic encephalopathy.Source: https://smhs.gwu.edu/news/new-study-finds-thalamus-wakes-brain-during-developmentlast_img read more

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Biologists analyze available methods of targeted drug delivery to malignant tumors

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first_imgReviewed by James Ives, M.Psych. (Editor)Apr 9 2019A team of biologists from Sechenov First Moscow State Medical University and Lobachevsky University (Nizhny Novgorod) analyzed available methods of targeted drug delivery to malignant tumors. Individual approaches to cancer therapy limit the influence of drugs on healthy tissues and reduce side effects. The results of the study were published in the Cancers journal. The research was supported by a grant issued by the Ministry of Science and Higher Education .The difference between healthy tissue and a tumor lies in the structure of its vasculature and changes in metabolism. In tumors blood vessels are formed chaotically, have different shapes and diameters, and exhibit closed ends and protrusions. The structure of lymphatic vessels also changes. A tumor and its vasculature grow at different speed causing oxygen and nutrients deficiency. The structure of the tissue and its metabolism changes, as well as the profile of molecules on the surface of tumor cells, and the cancer progresses. Taking these facts into consideration, one can develop methods of target antitumor drugs delivery without affecting healthy cells and causing unnecessary side effects.Currently, there are three main ways of targeted drug-to-tumor delivery: passive targeting that takes into account the structure of the vessels; active targeting in which an antitumor drug binds with a molecular target; and cell-mediated targeting.Due to the peculiarities of tumor vessels, large molecules can enter them relatively easily and accumulate in the tumor tissue. This phenomenon is known as enhanced permeability and retention effect, and passive drug targeting is based on it. However, this delivery method doesn’t always guarantee a desired effect. To increase its efficiency, individual therapies are developed on the basis of tumor characteristics. For example, the size of an agent may be optimized accordingly.Related StoriesDon’t Miss the Blood-Brain Barrier Drug Delivery (B3DD) Summit this AugustNew class of cancer-killing agents shows promise in destroying cancer stem cellsCommon cold virus strain could be a breakthrough in bladder cancer treatmentActive targeting complements the passive method. It increases the accumulation of a drug in tumor and the time of its retention. In their earlier work the team presented a multifunctional complex that leads to a synergistic effect of combined chemo- and radiotherapy agents. The base of the complex is a luminescent nanoparticle that contains a radioactive isotope 90Y used in radionuclide therapy. On the surface there is a bound highly active fragment of exotoxin A obtained from Pseudomonas aeruginosa (PE40). The complex binds with a marker protein of cancer cells, and its toxic agents affect the tumor. This treatment method works because tumor cells have different metabolism and molecular profiles than the cells of healthy tissues.Certain types of cells are able to penetrate tumor tissues and therefore can also be used to deliver drugs. Cell-mediated targeting extends the washout period, controls the release of the drug, and reduces general toxicity and side effects. This method has its limitations, but it is also very promising.”Having a choice between various treatment methods that take into account molecular and structural characteristics of a tumor and being able to adjust drug administration regime means approaching the goals of personalized medicine,” said Irina Balalayeva, a Candidate of Biological Sciences, Dean of the Department of Biophysics of the Institute of Biology and Biomedicine at Lobachevsky University, and a senior research associate of the laboratory of nanotheranostics at the Institute of Molecular Medicine, Sechenov Moscow State Medical University.Understanding the processes of nutrients and metabolic products transportation within a tumor, the peculiarities of its structure, and its interaction with immune system cells can help increase the efficiency of antitumor drug delivery and cancer treatment.Source: https://www.sechenov.ru/eng/news/141366/last_img read more

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