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11 days agoAston Villa defender Mings defiant after England debut

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first_imgAbout the authorFreddie TaylorShare the loveHave your say Aston Villa defender Mings defiant after England debutby Freddie Taylor11 days agoSend to a friendShare the loveTyrone Mings was delighted to make his England debut despite being subjected to racist abuse.The Aston Villa stopper started alongside Harry Maguire at centre-back in the 6-0 win over Bulgaria.Mings was the victim of racist taunts from the home crowd, but he was happy the Three Lions finished the match.Speaking after the game, he said: “It was a great occasion; I made my England debut. Slightly overshadowed by a few disappointing chants, which could be clearly heard on the pitch, but we showed a great response and ultimately we let the football do the talking.”I think the protocol was effective, and there was less chanting after that. We made a decision at half-time to come out and play the game, which we thought was the right thing to do.” last_img read more

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Oklahoma State Honoring Members Of Basketball Program Who Died In Plane Crash 14 Years Ago Today

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first_imgOklahoma State honors 2001 plane crash victims.On January 27th, 2001, the Oklahoma State basketball program suffered an unthinkable tragedy when eight members of its family (two players and six staffers and broadcasters) died in a plane crash while returning from a game in Colorado. In the years since that traumatic event, the 10 people who died in the crash –including the pilot and co-pilot–have been memorialized with a banner hanging in the rafters of OSU’s home court, Gallagher-Iba Arena, and a memorial located inside the Athletics Center. Also, each year, at the home game closest to the date of the crash, Oklahoma State honors the 10. This post from the Cowboys’ official athletics Instagram account has all the details on the ceremony before tonight’s game against Baylor: Very touching and appropriate tribute for those whose lives were inexplicably cut short, and it’s incredible to think 14 years has passed since this tragedy happened.last_img read more

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Thalamus controls development of normal sleep and waking states study finds

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first_imgReviewed by James Ives, M.Psych. (Editor)Oct 12 2018Consciousness requires continuous, internally generated activity in the brain. The modulation of this activity is the basis of the electroencephalogram (EEG) and of generation of sleep, dreams, and perception. Achieving such activity is thus an important milestone in normal brain maturation, which occurs around birth. Successful transition to this activity indicates a good prognosis for babies born prematurely and/or suffering from damage to the brain.To be functional as a dreaming, seeing, and thinking entity the brain need to achieve two milestones: continuity, which means that the brain is always active and state dependence, meaning brain activity is modulated by sleep, waking, and attention. The circuit mechanisms behind the development of continuity and state dependence in the brain have remained unknown, but have been widely assumed to be located in the cerebral cortex, the convoluted brain structure responsible for thought and perception.A team from the George Washington University (GW) has published a study in the Journal of Neuroscience suggesting instead that the thalamus, a tiny nucleus deep in the brain, actually controls the development of state dependence and continuity.”Our results indicate that cellular changes in the thalamus relay function may be critical drivers for the maturation of background activity,” Matthew Colonnese, PhD, associate professor of pharmacology and physiology at the GW School of Medicine and Health Sciences, said. “Humans undergo developmental transitions in brain activity before and near birth.”Related StoriesResearch team to create new technology for tackling concussionMercy Medical Center adds O-arm imaging system to improve spinal surgery resultsStudy provides new insight into longitudinal decline in brain network integrity associated with agingDrawing on previous work by Colonnese, his team used advanced techniques to record simultaneously from multiple brain regions to pinpoint the circuit change responsible for the acquisition of continuity and state dependence measured in the sensory cortex. They were surprised to learn that activity changes in the thalamus, rather than the local cortical circuitry or the interconnectivity of two structures, can explain most of these critical developmental milestones.”From a clinical perspective, certain things can go wrong in birth, like hypoxic-ischemic encephalopathy, brain injury caused by lack of oxygen to the brain, and the brain can revert to a state of discontinuity or never develop continuity,” said Colonnese. “These findings could help us understand the circuit basis of human EEG development to improve diagnosis and treatment of infants in vulnerable situations. By putting the development of the EEG on a mechanistic basis we hope to increase its utility in the clinic.”Colonnese and his team, which includes Yasunobu Murata, PhD, a research scientist in Colonnese’s lab at GW and co-author of the study, are working to develop a comprehensive atlas of EEG patterns and brain lesions that cause them to aid in this process.Now that they have established the thalamus is in control, he said, the next step is to further define what circuit changes occur in brain development so clinicians can pinpoint from an EEG what’s gone wrong in cases like hypoxic-ischemic encephalopathy.Source: https://smhs.gwu.edu/news/new-study-finds-thalamus-wakes-brain-during-developmentlast_img read more

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Biologists analyze available methods of targeted drug delivery to malignant tumors

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first_imgReviewed by James Ives, M.Psych. (Editor)Apr 9 2019A team of biologists from Sechenov First Moscow State Medical University and Lobachevsky University (Nizhny Novgorod) analyzed available methods of targeted drug delivery to malignant tumors. Individual approaches to cancer therapy limit the influence of drugs on healthy tissues and reduce side effects. The results of the study were published in the Cancers journal. The research was supported by a grant issued by the Ministry of Science and Higher Education .The difference between healthy tissue and a tumor lies in the structure of its vasculature and changes in metabolism. In tumors blood vessels are formed chaotically, have different shapes and diameters, and exhibit closed ends and protrusions. The structure of lymphatic vessels also changes. A tumor and its vasculature grow at different speed causing oxygen and nutrients deficiency. The structure of the tissue and its metabolism changes, as well as the profile of molecules on the surface of tumor cells, and the cancer progresses. Taking these facts into consideration, one can develop methods of target antitumor drugs delivery without affecting healthy cells and causing unnecessary side effects.Currently, there are three main ways of targeted drug-to-tumor delivery: passive targeting that takes into account the structure of the vessels; active targeting in which an antitumor drug binds with a molecular target; and cell-mediated targeting.Due to the peculiarities of tumor vessels, large molecules can enter them relatively easily and accumulate in the tumor tissue. This phenomenon is known as enhanced permeability and retention effect, and passive drug targeting is based on it. However, this delivery method doesn’t always guarantee a desired effect. To increase its efficiency, individual therapies are developed on the basis of tumor characteristics. For example, the size of an agent may be optimized accordingly.Related StoriesDon’t Miss the Blood-Brain Barrier Drug Delivery (B3DD) Summit this AugustNew class of cancer-killing agents shows promise in destroying cancer stem cellsCommon cold virus strain could be a breakthrough in bladder cancer treatmentActive targeting complements the passive method. It increases the accumulation of a drug in tumor and the time of its retention. In their earlier work the team presented a multifunctional complex that leads to a synergistic effect of combined chemo- and radiotherapy agents. The base of the complex is a luminescent nanoparticle that contains a radioactive isotope 90Y used in radionuclide therapy. On the surface there is a bound highly active fragment of exotoxin A obtained from Pseudomonas aeruginosa (PE40). The complex binds with a marker protein of cancer cells, and its toxic agents affect the tumor. This treatment method works because tumor cells have different metabolism and molecular profiles than the cells of healthy tissues.Certain types of cells are able to penetrate tumor tissues and therefore can also be used to deliver drugs. Cell-mediated targeting extends the washout period, controls the release of the drug, and reduces general toxicity and side effects. This method has its limitations, but it is also very promising.”Having a choice between various treatment methods that take into account molecular and structural characteristics of a tumor and being able to adjust drug administration regime means approaching the goals of personalized medicine,” said Irina Balalayeva, a Candidate of Biological Sciences, Dean of the Department of Biophysics of the Institute of Biology and Biomedicine at Lobachevsky University, and a senior research associate of the laboratory of nanotheranostics at the Institute of Molecular Medicine, Sechenov Moscow State Medical University.Understanding the processes of nutrients and metabolic products transportation within a tumor, the peculiarities of its structure, and its interaction with immune system cells can help increase the efficiency of antitumor drug delivery and cancer treatment.Source: https://www.sechenov.ru/eng/news/141366/last_img read more

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Maternal prepregnancy surgery linked to increased risk of opioid withdrawal in newborns

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first_imgUse of opioids for pain control after surgery may increase the risk of opioid dependence in women and withdrawal in their newborns.”Study’s lead author Dr. Nathalie Auger, professor at the University of Montreal’s School of Public Health Related StoriesIt is okay for women with lupus to get pregnant with proper care, says new studyTen-fold rise in tongue-tie surgery for newborns ‘without any real strong data’Cannabis use during pregnancy may cause premature birth”We found that mothers who had surgery before pregnancy had 1.6 times the risk of neonatal abstinence syndrome – that is, opioid withdrawal symptoms in their future newborns – perhaps because opioid use continues after surgery.”The large study included data on almost 2.2 million births in Quebec between 1989 and 2016. Of those, 2,346 newborns had neonatal abstinence syndrome and, of these, 1,052 had mothers who underwent prepregnancy surgery (14.9 per 10,000 babies) compared with 1,294 babies (8.8per 10,000) born to mothers who did not have surgery.Multiple surgeries, younger age at surgery, longer time between surgery and pregnancy, and cardiovascular, thoracic, urologic, or neurosurgery were associated with the largest risk of neonatal abstinence syndrome. There was also a strong association with general anesthesia, perhaps because this type of anesthesia is used in more complex surgeries, which can require longer use and higher dosage of pain relievers.”Physicians have the potential to prevent neonatal abstinence syndrome with careful postoperative pain management in young women,” Auger said. “Opioids continue to be overprescribed, despite efforts made to optimize postsurgical pain control through improvement of surgical guidelines and use of multipronged approaches with nonopioid painkillers or local anesthetics.”Limiting postoperative opioid exposure, reducing overprescribing and screening for opioid use in pregnant women who have had previous surgery may help reduce the risk of neonatal abstinence syndrome, she added. Source:University of MontrealJournal reference:Auger, N. et al. (2019) Maternal prepregnancy surgery and risk of neonatal abstinence syndrome in future newborns: a longitudinal cohort study. CMAJ. doi.org/10.1503/cmaj.181519. Reviewed by James Ives, M.Psych. (Editor)Jul 15 2019Babies whose mothers underwent surgery before pregnancy have an increased risk of opioid withdrawal symptoms at birth, according to a new study done at the University of Montreal Hospital Research Centre (CRCHUM) and published in the Canadian Medical Association Journal.last_img read more

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Higher levels of physical activity not linked to greater volume or activity

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first_img Source:University of GranadaJournal reference:Acosta, F.M. et al. (2019) Association of objectively measured physical activity with brown adipose tissue volume and activity in young adults. Journal of Clinical Endocrinology and Metabolism. doi.org/10.1210/jc.2018-01312. Studies that analyze the effect of regular physical activity, from a molecular point of view, are necessary to help us understand the mechanisms that mediate the therapeutic effects of exercise in humans.”Francisco Miguel Acosta Manzano, doctoral student in Biomedicine, UGR’s International School for Postgraduate Studies Reviewed by James Ives, M.Psych. (Editor)Jul 5 2019A study conducted by researchers from the University of Granada (UGR) has found that, in contrast to scientific thinking to date, higher levels of physical activity are not linked to a greater volume or activity of brown adipose tissue (BAT). BAT is a thermogenic organ that burns glucose and fats, releasing the energy that is produced in the form of heat.When BAT is activated, it consumes glucose and lipids, partially preventing them from being stored in other tissues, such as white adipose tissue (or common fat), which is located, for example, around the abdomen.Over the last decade, several studies have unequivocally confirmed the presence of BAT in human adults. BAT is a thermogenic organ equipped to dissipate energy in the form of heat through the so-called “uncoupling protein”. Therefore, it has been postulated that generating a greater volume of BAT, and increasing its activity, could be a potential strategy for combatting obesity and associated comorbidities, such as type 2 diabetes.Researchers have tended to channel their efforts into identifying strategies to help improve BAT function safely over the long term. On this premise, previous studies have suggested that raising levels of physical activity could be an effective strategy for increasing the volume and activity of BAT. However, the data from extant studies conducted on humans are both scarce and contradictory.In this new study, published in the Journal of Clinical Endocrinology and Metabolism, the UGR scientists investigate, for the first time, the link between objectively-measured levels of physical activity and the quantity and activity of BAT. The latter are measured by means of proton-emission tomography combined with computed tomography (using a radiopharmaceutical known as18F-Fluorodeoxyglucose). This study was performed on a sample of sedentary young adults, whose BAT was measured (the largest cohort of its kind to date). The sample comprised 87 women and 43 men, with an average age of 22 years.Related StoriesLiver fat biomarker levels linked with metabolic health benefits of exercise, study findsResearchers to examine if a ‘snacktivity’ approach to physical activity is effective in improving healthMobile phone app may help boost and maintain physical activity in womenThis study was part of the ACTIBATE (Activating Brown Adipose Tissue Through Exercise) project (http://profith.ugr.es/actibate), which was implemented by the University of Granada during 2014-2017. It was funded by Spain’s then-Ministry of Economy and Competitiveness, via the Health Research Fund of the Carlos III Institute of Health (PI13/01393).No link identifiedThe authors of the article observed that there was no link between the levels of physical activity and the volume and activity of BAT, even after adjusting the analyses for covariables that could be influencing the results. Nor was the time spent being sedentary associated with the volume and activity of BAT, they noted. The authors concluded that, although physical activity is one of the main interventions recommended in the prevention of chronic diseases such as obesity and type 2 diabetes, other mechanisms beyond an increase in the volume and activity of BAT could be mediating its beneficial metabolic effects. These findings contradict the results of previous studies, and call into question the role of exercise in improving BAT function.last_img read more

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Toyota to assemble Lexus in Canada Trudeau

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first_img This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Toyota invests Can$1.4 billion in Canada plants Japanese automaker Toyota will assemble two models of its Lexus in Canada starting in 2022, Prime Minister Justin Trudeau announced Monday. © 2019 AFP Explore furthercenter_img It will be the first time that the Lexus NX and NX hybrid sport utility vehicles are produced outside of Japan, Trudeau said.He told a news conference the Cambridge, Ontario assembly plant 50 miles (80 kilometers) west of Toronto would supply the Canadian and US markets.Toyoto announced last year it would invest Can$1.4 billion (US$1 billion) in its two Ontario facilities, in Cambridge and in nearby Woodstock, which assembles its RAV4 vehicles.It plans to concentrate its North American production of hybrid vehicles in the province. Ottawa also pitched in Can$110 million.The two assembly lines can build over 500,000 vehicles annually, making Toyota the largest automotive manufacturer in Canada. Citation: Toyota to assemble Lexus in Canada: Trudeau (2019, April 29) retrieved 17 July 2019 from https://phys.org/news/2019-04-toyota-lexus-canada-trudeau.html The new Lexus NX luxury SUV is unveilded at the Toyota Cambridge plant in Cambridge, Ontario, on April 29, 2019last_img read more

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Molinari sighting at Scottish Open as Edoardo ties for lead

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first_img(Reuters) – Edoardo Molinari was among many to take advantage of ideal conditions at the Scottish Open on Thursday, vaulting into a four-way share of the first-round lead in North Berwick.Edoardo, older brother of reigning British Open champion Francesco, carded eight-under-par 63, a score matched by fellow Italian Nino Bertasio, American Matt Kuchar and France’s Romain Wattel at the Renaissance Club.While Francesco is having a week off to prepare for next week’s Open at Royal Portrush, Edoardo is attempting to qualify as one of the top three finishers this week not also already exempt.Soft conditions and little breeze left the course at the mercy of the field on a day when more than half the players broke 70. Related News Related News Golf 11 May 2019 Woods, Koepka, Molinari to tee off early in first round at PGA Golf 11 Jul 2019 Golf – Social media critics no problem but not granny, says Kucharcenter_img {{category}} {{time}} {{title}} Northern Irishman Rory McIlroy and American Justin Thomas carded 67, while former champion Rickie Fowler was among just a handful of players to struggle, shooting 71. (Reporting by Andrew Both in Cary, North Carolina, editing by Ed Osmond) Golf 07 Jul 2019 American Daly not allowed to use golf cart at British Openlast_img read more

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