An international team of researchers has decoded the genome of a creature whose evolutionary history is both enigmatic and illuminating: the African coelacanth. A sea-cave dwelling, 5-foot-long fish with limblike fins, the coelacanth was once thought to be extinct. A living coelacanth was discovered off the African coast in 1938, and since then, questions about these ancient-looking fish have loomed large.Coelacanths today closely resemble the fossilized skeletons of their ancestors of more than 300 million years ago. Their genome confirms what many researchers had long suspected: Genes in coelacanths are evolving more slowly than in other organisms.“We found that the genes overall are evolving significantly slower than in every other fish and land vertebrate that we looked at,” said Jessica Alföldi, a research scientist at the Broad Institute of Harvard and MIT and co-first author of a paper on the coelacanth genome, which appears in Nature this week. “This is the first time that we’ve had a big enough gene set to really see that.”Researchers hypothesize that this slow rate of evolution may be because coelacanths simply have not needed to change: They live primarily off the Eastern African coast (a second coelacanth species lives off the coast of Indonesia), at ocean depths where relatively little has changed over the millennia.“We often talk about how species have changed over time,” said Kerstin Lindblad-Toh, scientific director of the Broad Institute’s vertebrate genome biology group and senior author. “But there are still a few places on earth where organisms don’t have to change, and this is one of them. Coelacanths are likely very specialized to such a specific, non-changing, extreme environment — it is ideally suited to the deep sea just the way it is.”Because of their resemblance to fossils dating back millions of years, coelacanths today are often referred to as “living fossils” — a term coined by Charles Darwin. But the coelacanth is not a relic of the past brought back to life: It is a species that has survived, reproduced, but changed very little in appearance for millions of years. “It’s not a living fossil; it’s a living organism,” said Alföldi. “It doesn’t live in a time bubble; it lives in our world, which is why it’s so fascinating to find out that its genes are evolving more slowly than ours.”The coelacanth genome has also allowed scientists to test other long-debated questions. For example, coelacanths possess some features that look oddly similar to those seen only in animals that dwell on land, including “lobed” fins, which resemble the limbs of four-legged land animals (known as tetrapods). Another odd-looking group of fish known as lungfish possesses lobed fins, too. It is probable that one of the ancestral lobed-finned fish species gave rise to the first four-legged amphibious creatures to climb out of the water and up onto land, but until now, researchers could not determine which of the two was the likelier candidate.In addition to sequencing the full genome — nearly 3 billion “letters” of DNA — from the coelacanth, the researchers also looked at RNA content from the coelacanth (both the African and Indonesian species) and from the lungfish. This information allowed them to compare genes in use in the brain, kidneys, liver, spleen, and gut of lungfish with gene sets from coelacanths and 20 other vertebrate species. Their results suggested that tetrapods are more closely related to lungfish than to the coelacanth.However, the coelacanth is still a critical organism to study to understand what is often called the water-to-land transition. The lungfish may be more closely related to land animals, but its genome remains inscrutable: At 100 billion letters in length, the lungfish genome is simply too unwieldy for scientists to sequence, assemble, and analyze. The coelacanth’s more modest genome (comparable in length to our own) is yielding valuable clues about the genetic changes that may have allowed tetrapods to flourish on land.By looking at what genes were lost when vertebrates came on land as well as what regulatory elements — parts of the genome that govern where, when, and to what degree genes are active — were gained, the researchers made several unusual discoveries:Sense of smell. The team found that many regulatory changes influenced genes involved in smell perception and detecting airborne odors. They hypothesize that as creatures moved from sea to land, they needed new means of detecting chemicals in the environment around them.Immunity. The researchers found a significant number of immune-related regulatory changes when they compared the coelacanth genome to the genomes of land animals. They hypothesized that these changes may have been part of a response to new pathogens encountered on land.Evolutionary development. Researchers found several key genetic regions that may have been “evolutionarily recruited” to form tetrapod innovations such as limbs, fingers and toes, and the mammalian placenta. One of these regions, known as HoxD, harbors a particular sequence that is shared across coelacanths and tetrapods. It is likely that this sequence from the coelacanth was co-opted by tetrapods to help form hands and feet.Urea cycle. Fish get rid of nitrogen by excreting ammonia into the water, but humans and other land animals quickly convert ammonia into less-toxic urea using the urea cycle. Researchers found that the most important gene involved in this cycle has been modified in tetrapods.The coelacanth genome may hold other clues for researchers investigating the evolution of tetrapods. “This is just the beginning of many analyses on what the coelacanth can teach us about the emergence of land vertebrates, including humans, and, combined with modern empirical approaches, can lend insights into the mechanisms that have contributed to major evolutionary innovations,” said Chris Amemiya, a member of the Benaroya Research Institute and co-first author of the Nature paper. Amemiya is also a professor at the University of Washington.Sequencing the full coelacanth genome was uniquely challenging for many reasons. Coelacanths are an endangered species, so samples available for research are almost nonexistent. This meant that each sample obtained was precious: Researchers would have “one shot” at sequencing the collected genetic material, according to Alföldi. But the difficulties of obtaining a sample and the challenges of sequencing it also knit the community together.Although the coelacanth genome offers some tantalizing answers, the research team anticipates that further study of the fish’s immunity, respiration, physiology, and more will lead to deep insights into how some vertebrates adapted to life on land, while others remained creatures of the sea.
Read Full Story The Department of Defense recently announced the winners of their 2020 Multidisciplinary University Research Initiative (MURI) program. The agency received 365 proposals and awarded 26 grants. In a rare feat, they selected two professors from the Department of Chemistry and Chemical Biology — Daniel Nocera and Kang-Kuen Ni — to lead multi-disciplinary teams in designing the next generation of military and commercial technology.“Modern science and engineering problems often intersect more than one scientific discipline,” said Bindu Nair, the deputy director for basic research at the Department of Defense, in a press release. Multidisciplinary effort “accelerates research progress to enable more rapid R&D breakthroughs by cross-fertilization of ideas, and can hasten the transition of basic research findings to practical applications.”Daniel Nocera, the Patterson Rockwood Professor of Energy, will use his MURI to work on oxygen harvesting and storage in the ocean. For example, if a diver descends into the deep sea with a limited amount of oxygen, could a tool let them extract oxygen from the surrounding waters and stay down there longer?Nocera and his multidisciplinary, cross-institution team of experts, which includes Jarad Mason, assistant professor of chemistry and chemical biology will design technology to harvest pure oxygen from undersea environments of different temperatures and depths. Ultimately, their work could help create the next generation of diving suits capable of extracting and storing oxygen mid-dive.Kang-Kuen Ni, the Morris Kahn Associate Professor of Chemistry and Chemical Biology and of Physics, will work on a problem of precision. A pioneer of ultracold chemistry, Ni has used colder and colder temperatures to forge molecules from atoms that would otherwise never react. Cooled to such extremes, atoms and molecules slow to a quantum crawl, their lowest possible energy state. There, she can manipulate molecular interactions with utmost precision. Recently, her lab performed the coldest chemical reaction and saw, for the first time, a slowed-down version of two molecules breaking and forming bonds.With her MURI, Ni has formed a team of experts from chemistry, quantum information, precision measurement and physics to take this work further and achieve the same level of control over molecules as she has over individual atoms. With that power, she will investigate how specific molecules behave in the quantum realm, which could lead to far more sensitive sensors, processors and transducers, as well as advanced material science and drug design. Her team’s work will also add more rungs on the ladder to quantum computers.Previously, the MURI helped launch technologies like laser frequency combs — now the gold standard in frequency control for precision in navigation and targeting — atomic and molecular self-assembly projects, which advanced nano-manufacturing, and the entire field of spintronics.This year’s 26 winning teams earned an average of $7 million for their five-year research projects. Nocera and Ni’s teams include collaborators from nine different institutions including Harvard.
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