爱上海,上海龙凤419,上海419论坛 – Powered by Coral Miller!

New ₡5000 ₡10000 and ₡50000 bills to circulate in August

Posted on by

first_imgCosta Rica’s Central Bank announced Tuesday that it will circulate three new banknotes of ₡5,000 ($10), ₡10,000 ($20) and ₡50,000 ($99) in August.Once the new bills are out, the old ones will need to be exchanged in banks. Beginning in December, only the Central Bank will exchange them.All new banknotes display images of former presidents: The ₡5,000 note is yellow and has the image of Alfredo González Flores, the green ₡10,000 bill shows three-time President José Figueres Ferrer and the ₡50,000 – purple – portrays the image of another three-timer, President Ricardo Jiménez Oreamuno.Following an introductory campaign for the new bills, Central Bank authorities explained that these also include security features to prevent counterfeiting, for example, translucent watermarks, color-changing shapes and textured images. Facebook Comments Related posts:Costa Rica circulates new ₡1,000 and ₡2,000 bills Old banknotes lose their value from January 1 Central Bank issues new improved ₡5,000 banknotes Central Bank: That ₡5,000 counterfeit bank note message is fakelast_img read more

Tagged: , , , , , , , , , , , .

Go back to the enewsletter Seabourn is enhancing

Posted on by

first_imgGo back to the e-newsletterSeabourn is enhancing its Ventures by Seabourn expedition programme in northern Europe this summer, giving guests on board Seabourn Quest new opportunities to experience the region’s picturesque destinations.Designed for small groups, Ventures by Seabourn excursions enable guests to explore stunning waterways and fjords, secluded inlets and scenic islands via Zodiac inflatable boats or double sea kayaks launched from the unique fold-out water sports marina on board all Seabourn vessels.The optional excursions are led by an expert team of scientists, scholars and naturalists with a guide-to-guest ratio of 1:14 maximum.Guests travelling on board Seabourn Quest during its northern Europe season will be offered more than 30 Ventures by Seabourn excursions this year, including:Puffins, Eidorers and Guillemots on Vigur Island – Discover Iceland’s small island of Vigur, home to a harmonious gathering of thousands of birds, a beautiful landscape and Europe’s smallest post office.Fjord Journey through Prins Christian Sund – Experience the dramatic high mountain faces and scoured rock massifs by Zodiac, while looking for icebergs and waterfalls engorged by meltwater.Extensive Fjord Exploration to Trollfjord – Join the resident naturalist on a Zodiac to explore the sheltered fjords of Norway and the Lofoten Islands, discovering flora and fauna while watching for moose.As part of Seabourn’s ongoing focus on enrichment, guests will also enjoy a strong on board academic program, with Seabourn Conversations from the ship’s impressive expedition team, including: Ignacio “Iggy” Rojas, Ventures Leader aboard Seabourn Quest and expedition cruising expert; Dr. Coleen Batey, a Senior Lecturer in Archaeology at the University of Glasgow; Luciano “Luqui” Bernacchi, a mountain, ski and naturalist guide who has more than 20 years of experience; and Kara Weller, an Alaska native with a background in research for universities on both sides of the Atlantic.“Building on the success of Ventures by Seabourn in Antarctica, our Northern Europe guests will have access to intimate and exclusive new ways to see this stunning landscape,” Seabourn Senior Vice President Global Marketing and Sales John Delaney said. “With a wide selection of exciting excursions and meaningful enrichment content led by a world class expedition team, Seabourn continues to ensure our guests experience the very best that our worldwide destinations have to offer.”Go back to the e-newsletterlast_img read more

Tagged: , , , , , , , , , .

The European Coalition for Cultural Diversity have

Posted on by

first_imgThe European Coalition for Cultural Diversity have called for a renewed effort by Europe to create a financial system of cultural support that meets the needs of the digital era.The group has organised a conference at the European Parliament in Brussels with the support of deputy Pervenche Bérès to push for the ending of a financial regime that it sees as penalising cultural production and benefiting large multinational corporations.The coalition has called for cultural goods sold via digital distribution platforms to benefit from the same tax breaks afforded to other cultural goods, and praised European countries that have levied VAT on digital books at the same rate as physical books as setting a good example.The group also called for an overhaul of taxes applied to cultural goods at a European level to prevent international groups avoiding their responsibilities, including the responsibility to support domestic cultural production.last_img read more

Tagged: , , , , , , , , , .

Latin American telco America Movil has upped its s

Posted on by

first_imgLatin American telco America Movil has upped its stake in Telekom Austria to a majority 50.8% after agreeing to buy some €743.4 million-worth of shares in the European operator.Announcing the deal this morning, Telekom Austria said that America Movil had agreed to buy 103.98 million shares representing approximately 23.47% of the share capital of Telekom Austria at a price of €7.15 per share.The deal, which comes after America Movil had initially offered to buy all shares of Telekom Austria, will see it own a total of 225.09 million shares in the business, representing roughly 50.80% of the share capital of Telekom Austria.According to terms of the offer, which expired last Thursday, payment is due to be made on or before July 24.America Movil acquired a 21% stake in Telekom Austria back in 2012 and last year announced plans to make a €7.2 billion bid for all issued and outstanding shares in KPN in the Netherlands.Telekom Austria claims roughly 23 million customers in central and eastern Europe. It offers services including IPTV, voice telephony and broadband internet and has a presence in eight countries – Austria, Bulgaria, Belarus, Croatia, Slovenia, Serbia, Macedonia and Liechtenstein.last_img read more

Tagged: , , , , , , , , , .

Order Postmates It Might Arrive Via an Autonomous Ford

Posted on by

first_imgDelivery Learn how to successfully navigate family business dynamics and build businesses that excel. The automaker is teaming up with Postmates for autonomous delivery trials. Add to Queue Order Postmates? It Might Arrive Via an Autonomous Ford. Next Article 2 min read Image credit: via PC Mag Free Webinar | July 31: Secrets to Running a Successful Family Businesscenter_img In the future, takeout, groceries and other things you order through the delivery startup Postmates might arrive via a self-driving Ford.The automaker is teaming up with Postmates for autonomous delivery trials. As part of this partnership, the companies plan to conduct pilot programs throughout the year to understand “how self-driving technology could change the delivery experience for consumers, enable brick-and-mortar retailers to reach new customer bases, and transform the way commerce moves,” Ford’s Vice President of autonomous vehicles and electrification Sherif Marakby wrote in a blog post.Postmates is an app and web-based service that connects customers with “local couriers who can deliver anything from any store or restaurant in minutes,” the company says on its website. Originally launched in its hometown of San Francisco, the service is now available in more than two dozen states and the District of Columbia (to see if it’s available in your area, head here).The companies hope this partnership leads to more efficient deliveries and helps consumers connect with small and local businesses in their area, according to Marakby.”The way commerce is moving around in cities is dramatically changing, and emerging technology will undoubtedly have an impact on the future of on-demand delivery,” Marakby wrote. “With the knowledge we’ll gain from our partnership with Postmates, we anticipate we’ll be able to better deploy self-driving technology in a way that can help people get what they need faster, while also supporting local businesses that are a big part of communities around the world.”Last year, Ford teamed up with Domino’s to carry out a self-driving pizza delivery experiment in Ann Arbor, Mich., using Ford’s Fusion Hybrid vehicles for deliveries. January 10, 2018 This story originally appeared on PCMag Reporter Angela Moscaritolo Register Now » –shareslast_img read more

Tagged: , , , , , , , , , , , .

Jony Ive Reportedly Felt That Tim Cook Wasnt Interested in Design

Posted on by

first_img Next Article –shares Steve Dent This story originally appeared on Engadget Jony Ive Reportedly Felt That Tim Cook Wasn’t Interested in Design Free Webinar | July 31: Secrets to Running a Successful Family Business 3 min read Image credit: Justin Sullivan/Getty Images via engadget Register Now » Jony Ive’s departure was made official last week, but may have begun years ago because of Apple’s shift in focus from design to operations, according to the WSJ and Bloomberg. Citing multiple unnamed sources, the reports stated that Ive was “dispirited” by Tim Cook’s lack of interest in design, especially considering the close synergy he shared with former Apple CEO Steve Jobs. At the same time, Ive was coming into Apple’s offices much less often than before, “straining the cohesion central to product development,” the WSJ stated.Ive reportedly started showing up at Apple’s offices less often after the release of the Watch. Rather than an iPhone peripheral, Ive saw it was a fashion accessory, clashing with Apple executives over how to position it. The resulting device, at $349, sold only 10 million units (a quarter of the forecast), while “thousands” of copies of the $17,000 gold version went unsold, according to the WSJ.Much like many Apple fans, Ive was supposedly frustrated with the change in company culture from the one — established by he and Jobs — where design ruled. He was not only disappointed by the fact that Tim Cook “showed little interest in the product development process,” but also that Apple’s Board was increasingly filled with directors that had no experience in Apple’s business.Ive was promoted to Chief Design Officer shortly after the launch of the Watch, but only came to the office a couple of days a week, according to Bloomberg. Meetings were often moved to San Francisco where he lived, and even to hotels, homes of employees and other venues. “The team craved being around him,” said a WSJ source close to Apple leadership at the time. “He’s engaging. Him being around less was disappointing.”Ive created numerous iconic projects with Apple, often as a result of discussions, debates and arguments with Jobs. That includes iconic products like the iPhone, iPad, iPod, MacBook Air, Apple Watch and even Apple’s new headquarters. However, recent products like the HomePod and iPhone X models have enjoyed less success, and Apple recently killed its AirPower charging pad, which Ive imagined as a catchall for Apple devices. According to the WSJ, however, “engineering tests found it behaved more like a dorm-room hot plate.”Now his new design firm, “LoveFrom,” will reportedly be paid “millions of dollars a year to continue to work with Apple,” the WSJ said. That could give Ive the best of both worlds, only working on the stuff he wants for Apple without having to deal with internal politics. Add to Queue Ive was often absent from key product meetings, according to the WSJ. July 1, 2019 Learn how to successfully navigate family business dynamics and build businesses that excel. Applelast_img read more

Tagged: , , , , , , , , , , , .

A Brief History of Ubers Controversies

Posted on by

first_img Learn how to successfully navigate family business dynamics and build businesses that excel. Register Now » Erin Griffith A Brief History of Uber’s Controversies Free Webinar | July 31: Secrets to Running a Successful Family Business –shares November 18, 2014 This story originally appeared on Fortune Magazine Next Article Silicon Valley’s most valuable startup could also be its most toxic. A scoop from BuzzFeed illuminated as much last night. At a private dinner, Emil Michael, Uber’s SVP of business, suggested a plan to spend $1 million on a revenge campaign against journalists, in particular Sarah Lacy, a writer who has criticized the ridesharing startup. Michael’s apparent plan involves using data, which the company has access to through its app, to dig up information about Lacy’s personal life, then publicly distribute the compromising information. He also talked about hiring opposition researchers to dig up more dirt.The news quickly ricocheted around Twitter. Taken on its own, the story may not have stirred up such a fierce reaction. But the sheer volume of Uber scandals is difficult to ignore. With each new one, Uber’s three constituents – customers, investors and drivers – are questioning the $18.2 billion company. (Kalanick issued an apology today on Twitter.) Below, a look at what got us here:Drivers behaving badlyAn Uber driver has been accused of kidnapping a female rider.An Uber driver was accused of attacking a rider in the head with a hammer.An Uber driver assaulted a rider. Another Uber driver, whopassed Uber’s background check, assaulted and abused a rider.An Uber driver hit and killed a six-year-old girl. The company avoided liability because its drivers are independent contractors rather than employees.An Uber driver was accused of rape. Another was accused of fondling a passenger.Driver treatmentUber drivers in New York and San Francisco have held protests and strikes for better pay and treatment.Uber has been accused of pushing its drivers intosubprime auto loans.Sexist commentsCEO Travis Kalanick joked about how desirable he is to women, thanks to Uber’s success. “We call that Boob-er,” he told a reporter.Sexist adsUber promoted its services in France by pairing riders with “hot chick” drivers and asking, “Who said women don’t know how to drive?”Playing dirty against competitorsKalanick has repeatedly trash-talked rival Lyft, at one point calling the service a clone on Twitter. Uber’s elaborate plans to sabotage Lyft include aggressively recruiting Lyft’s drivers and cancelling rides on the service to waste the drivers’ time.Uber has even tried to kneecap Lyft’s fundraising (whichFortune’s Dan Primack has argued is fair game; venture investor Fred Wilson disagrees).Playing dirty with the mediaUber tried to plant a fake story that painted a positive picture of life as an Uber driver in LA Weekly after the publication ran a critical story.Surge pricing during emergenciesUber’s famous free-market pricing strategy did not make an exception for Hurricane Sandy, when many New Yorkers were displaced and the cost of taking an Uber car doubled. After complaints, the company said it would cap surge-pricing in emergencies.Regulatory fights and protestsUber tussles with the legacy black car and taxi industry in almost every city it enters. Many cities have tried to outlaw the service. When Berlin banned Uber, the company flouted the government and continued to operate. In other instances, Uber’s presence that causes the commotions. In France, a protest of Uber got physical when an Uber car’s windows were broken and its tires slashed. In London, a protest stopped traffic.Now, Uber can’t even release an integration with Spotifywithout writers pointing out that the partnership “furthers the ongoing logistical process of dehumanizing Uber drivers.” That was supposed to be a fluffy product announcement. But seen through the lens of Uber’s toxic history, nothing is. 4 min read Uber Add to Queuelast_img read more

Tagged: , , , , , , , .

Samsung Mobile Recovery Suffers Blow as Galaxy Notes Catch Fire

Posted on by

first_img Samsung Mobile Recovery Suffers Blow as Galaxy Notes ‘Catch Fire’ –shares Image credit: Reuters | Kim Hong-Ji Next Article The recovery in Samsung Electronics Co. Ltd.’s mobile business suffered a blow on Thursday as reports of exploding batteries forced the firm to delay shipments of Galaxy Note 7 smartphones, and knocked $7 billion off its market value.Investors drove the stock to two-week lows after the global smartphone leader told Reuters late on Wednesday the shipments had been delayed for quality control testing, and that shipments to South Korea’s top three mobile carriers had been halted.Faults with the new premium flagship device could deal a major blow to the South Korean giant, which was counting on the Galaxy Note 7 to maintain its strong mobile earnings momentum against Apple Inc.’s new iPhones expected to be unveiled next week.”This is some major buzz-kill for Samsung, especially given all of the hard-earned excitement that products like the Note 7 have been garnering lately,” IDC analyst Bryan Ma said.”The pending Apple launch puts all the more pressure for them to contain this quickly. The timing of this couldn’t have been worse.”Samsung did not comment on what problem it was trying to address or whether other markets were affected besides South Korea.Sister company Samsung SDI Co. Ltd. said that while it was a supplier of Galaxy Note 7 batteries, it had received no information to suggest the batteries were faulty.Several people posted images and videos of charred Galaxy Note 7s online and said their phones had caught on fire.”Be careful out there, everyone rocking the new Note 7, might catch fire y’all,” one user said in a YouTube clip showing a burnt Note phone. It was not immediately possible to confirm the veracity of the clip.Samsung’s shares, which hit a record high of 1.694 million won last week, fell 2 percent, and Samsung SDI tumbled 6.1 percent, versus a 0.1 percent fall for the broader market.Several South Korean media reports, without citing direct sources, said Samsung will soon announce a plan to recall affected Note 7 phones and replace their batteries as opposed to giving the users a new device. A Samsung spokesman declined to comment on the reports.Damage controlLast year, production problems for the curved displays for the Galaxy S6 edge model resulted in disappointing sales, and Samsung risks a repeat this year if it cannot address the Galaxy Note 7 problems quickly.Its mobile profit is on track to post annual growth for the first time in three years, thanks to robust sales of the Galaxy S7 and S7 edge devices that it launched in March to critical acclaim.The Galaxy Note 7 received similar praise, raising expectations for strong sales in the second half. Samsung said in August demand for the new handset, priced at 988,900 won ($882) in South Korea, was far exceeding supply, pushing the firm to delay the launch in some markets.HDC Asset Management fund manager Park Jung-hoon said it now appeared inevitable that Samsung’s smartphone average selling price and profits would miss lofty second-half expectations.”Apple is supposed to show off the iPhone 7 next week and this issue has emerged, so the current state of things do not look good,” he said.Though a components pick-up will buttress overall profits, Park said mobile operating profit might decline by up to 200 billion won for July-September.The mobile division accounted for about 54 percent of Samsung Electronics’ January-June operating profit of 14.8 trillion won.Hyundai Securities said in a report that the Galaxy Note 7’s problems should be resolved within a “few weeks”.The brokerage retained its third-quarter operating profit forecast of 8.5 trillion won.(Reporting by Se Young Lee; Editing by Stephen Coates and Simon Cameron-Moore) 2019 Entrepreneur 360 List A model demonstrates iris recognition function of Galaxy Note 7 new smartphone. Faults with the new premium flagship device could be a major setback for the South Korean giant. This story originally appeared on Reuterscenter_img The only list that measures privately-held company performance across multiple dimensions—not just revenue. 4 min read Reuters Add to Queue Samsung Galaxy September 1, 2016 Apply Now »last_img read more

Tagged: , , , , , , , , , .

SAS Again Named a Leader for Multichannel Marketing Hubs in Gartners Magic

Posted on by

first_imgThe rise in artificial intelligence (AI)-powered marketing helps brands accelerate the value delivered from data to increase customer profitability, streamline marketing operations and foster brand loyalty. Embedded, AI-powered analytics and real-time decisioning capabilities featured in the SAS Customer Intelligence technology optimize every phase of the customer journey and ultimately elevate the customer experience.SAS believes its market advantage is confirmed by Gartner’s evaluation of SAS Customer Intelligence 360, a comprehensive multichannel marketing solution grounded in AI and machine learning processes. The company was positioned highest for ability to execute in the 2019 Magic Quadrant for Multichannel Marketing Hubs.The solution’s advanced analytics functionality enables customer-level data and analysis, as well as predictive analytics, journey analytics and customer profile management. SAS Customer Intelligence 360 helps marketers exploit digital and offline data with practical self-learning AI applications and guided analytics for successful campaign orchestration.Marketing Technology News: SalesLoft Scoops $70 Million Series D to Fuel Growth in Sales TechnologyGartner says that Leaders “consistently do considerably better in overall multichannel marketing performance for basic and advanced campaigns, and for integration with digital marketing. They have high market visibility, high market penetration, strong market momentum and a strategic vision for growing the multichannel marketing hub business.” Gartner defines the multichannel marketing hub as a “technology that orchestrates a company’s communications with and offers to customer segments across multiple channels. These include websites, mobile, social, direct mail, call centers, paid media and email.”“AI is revolutionizing how marketing leaders can design and deliver customer experiences – synching digital and offline interactions,” said Wilson Raj, Global Director of Customer Intelligence for SAS. “AI and real-time decisioning is at the heart of SAS Customer Intelligence 360 – allowing brands to deliver personalization at scale, embrace a test-and-learn approach, and continuously engage with prospects and consumers efficiently.”Marketing Technology News: Bidalgo Launches Industry First Asset-Level Data for Google App Campaigns to Give App Marketers Greater Accuracy and ControlLearn more about elevating customer experiences with SAS Customer Intelligence. *Gartner, “Magic Quadrant for Multichannel Marketing Hubs,” by Noah Elkin, Adam Sarner, Benjamin Bloom, Joseph Enever, Colin Reid. 18 April 2019.Marketing Technology News: Snap Inc. Names Kenny Mitchell Chief Marketing Officer Artificial IntelligenceGartnerMagic QuadrantMarketing TechnologyMultichannel Marketing HubsNewsSAS Customer Intelligence Previous ArticleMuleSoft is the Only Company Named a Leader in Both the Gartner Magic Quadrant for Enterprise Integration Platform as a Service (iPaaS) and the Magic Quadrant for Full Life Cycle API ManagementNext ArticleBlis, WBR Insights and Future Stores Study Shows 91% of Retailers Are Embracing Digital Strategies to Build Loyalty to Physical Stores SAS Again Named a Leader for Multichannel Marketing Hubs in Gartner’s Magic Quadrant 2019 PRNewswireApril 29, 2019, 6:18 pmApril 29, 2019 last_img read more

Tagged: , , , , , .

Autism could be detected early using a hearing test finds research

Posted on by

first_img Source:http://jaoa.org/article.aspx?articleid=2720605&resultClick=1 At present diagnosis of autism is usually made around the age of four using tests that need speech abilities. Autism is part of the autism spectrum disorders (ASD) that has a variety of manifestations. This new study from the team at the Lake Erie College of Osteopathic Medicine in Pennsylvania says that there could be hearing problems in these children much before they learn to speak. These can be detected using tests.The test that the researchers have suggested is called the stapedial reflex testing or the acoustic reflex testing. This test measures the changes in pressure of the middle ear in response to sounds. This can assess the sensitivity of the patient to a wide range of sound frequencies. Randy Kulesza, professor of anatomy and team leader said in a statement, “Often people with autism suffer from hypersensitivity, meaning even relatively quiet sounds can feel like overwhelming noise… If parents and physicians understand that from the start, they can work to acclimate the child’s sensitivity and make his or her experience of the world much less intense and frightening.”Related StoriesStudy offers new clues to autism’s underlying biologyEyes hold clues to effective treatment of severe autism, study showsProblem behaviors may provide clues on gastrointestinal issues in children with autismAccording to Kulesza, newborns these days have their hearing tested and the results are usually binary saying if the child can hear or not. He explained that this stapedial reflex testing can provide a deeper understanding of various types of dysfunctions. This would mean that interventions can be started earlier before the symptoms appear. “Especially early in life, the brain is very plastic, meaning the right early interventions can literally train out those deficits,” Kulesza explained. “The person might not be perfectly neuro-typical but such interventions can improve function,” said Kulesza.The study team noted that children with ASD have problems with their hearing. Hearing is an important part of speech-language development which further affects the social-emotional development of the child. So if the hearing functions are addressed early, the quality of life of the child later could be improved, they suggest.Kulesza said more research in this area is needed to find the auditory interventions that could help these children. He added that acoustic reflex testing at present is not a diagnostic tool for detecting ASD. However if a child has tested positive on this, they may be started on early interventions so that their potentials are maximised. By Dr. Ananya Mandal, MDJan 8 2019New research shows that a simple non-invasive hearing test early in life could predict the diagnosis of autism. The results of this study, titled ‘Structural and Functional Aberrations of the Auditory Brainstem in Autism Spectrum Disorder’, is published in the latest issue of the The Journal of the American Osteopathic Association (JAOA).center_img Autism could be detected early using a hearing test finds research. Image Credit: Midkhat Izmaylovlast_img read more

Tagged: , , , , , , , .

NIHfunded researchers develop new assay to measure success of HIV cure strategies

Posted on by

first_imgReviewed by James Ives, M.Psych. (Editor)Jan 31 2019Scientists funded by the National Institutes of Health have developed a new assay to accurately and easily count the cells that comprise the HIV reservoir, the stubborn obstacle to an HIV cure. This advance will enable researchers who are trying to eliminate the HIV reservoir to clearly understand whether their strategies are working. The research was supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of NIH.The HIV reservoir consists of infected cells containing DNA molecules that encode HIV proteins. These cells have entered a resting state in which they do not produce any parts of the virus. Scientists have found that the HIV DNA–or “provirus”–inside resting cells is usually so defective that it cannot generate new virus particles. However, most available tools to measure the HIV reservoir cannot distinguish intact proviruses, which can replicate themselves, from the vast excess of defective proviruses.Related StoriesPrevalence of anal cancer precursors is higher in women living with HIV than previously reportedNovel method can help clinicians identify individuals most in need of PrEPHIV therapy leaves unrepaired holes in the immune system’s wall of defenseA team led by Robert F. Siliciano, M.D., at Johns Hopkins University School of Medicine analyzed DNA sequences from more than 400 HIV proviruses taken from 28 people with HIV. Among these proviruses, the scientists mapped two types of flaws: deletions and lethal mutations. The researchers then developed strategically placed genetic probes that could distinguish the deleted or highly mutated HIV proviruses from the intact ones. Finally, the scientists developed a nanotechnology-based method to analyze one provirus at a time with these probes to determine how many proviruses in a sample are intact.The researchers demonstrated that their method can readily and accurately measure the number of rare, intact proviruses that make up the HIV reservoir. The hope is that this new method will speed HIV research by allowing scientists to easily quantify the number of proviruses in an individual that must be eliminated to achieve a cure.Source: https://www.niaid.nih.gov/news-events/nih-supported-scientists-develop-tool-measure-success-hiv-cure-strategieslast_img read more

Tagged: , , , , , , , .

AfricanAmericans in major US cities more likely to live in trauma deserts

Posted on by

first_imgReviewed by James Ives, M.Psych. (Editor)Mar 11 2019African-Americans in major U.S. cities are significantly more likely to live in “trauma deserts” with limited access to advanced emergency medical care, according to new research from the University of Chicago Medicine. The study also shows the academic medical center’s new Level 1 Trauma Center led to a seven-fold reduction in Chicago’s access disparity.The findings, published March 8 in the Journal of the American Medical Association’s Network Open, are the first to be released about the impact of UChicago Medicine’s adult Level 1 Trauma Center. Adult trauma services at the hospital began in May 2018.”So much of the advocacy for the trauma center was framed in terms of racial equity,” said Elizabeth Tung, MD, MS, a primary care physician and instructor of medicine at UChicago Medicine who was the paper’s first author. “But we realized no previous studies had addressed trauma access through the lens of race/ethnicity – not just looking at Chicago, but comparing our city to other communities as well.”The research team examined access to trauma care in Chicago, New York and Los Angeles using a geospatial analysis that compared the location of designated trauma centers with the racial and ethnic composition of the cities’ census tracts. The project included only Level 1 and Level 2 Trauma Centers, which are able to provide medical care to patients with the most serious injuries.Using a standard established in previous research from colleagues at other hospitals, the team defined a “trauma desert” as any urban community that is at least five miles away from advanced trauma care. While many suburban and rural communities are significantly further away from trauma care, Tung said dense urban communities must be assessed differently.”Five miles in a rural area is probably five minutes away, but in an urban area that same distance could be 15 minutes or it could be two hours away – it entirely depends on traffic congestion,” Tung said. “The kind of care in urban trauma also differs from that in rural areas – the types of trauma are generally different, the patient volume is higher and the injuries are more severe.”Trauma centers provided advanced emergency medical care for patients with critical injuries, including those from motor vehicle accidents, falls, shootings and stabbings.Related StoriesAMSBIO offers new, best-in-class CAR-T cell range for research and immunotherapyResearch sheds light on sun-induced DNA damage and repairHome-based support network helps stroke patients adjust after hospital dischargeIn Chicago, the team found that 73 percent of census tracts with a mostly black population were located in trauma deserts. Until UChicago Medicine’s trauma center opened 10 months ago on its Hyde Park medical campus, residents of those communities had 8.5 times higher odds of being farther away from trauma care than people living in the city’s white-majority census tracts. The new trauma center reduced this disparity by nearly 7-fold, to 1.6 times.”Since we opened the trauma center nearly one year ago in May, the disparity in access to adult trauma care has been significantly lessened for African-Americans in Chicago,” said Selwyn Rogers, Jr., MD, MPH, a professor of surgery and the director of UChicago Medicine’s trauma center, which has treated more than 2,000 trauma patients.In New York City, just 14 percent of African-American communities were located in trauma deserts. In Los Angeles, 89 percent of African-American communities were located in trauma deserts, although very few census tracts in Los Angeles remain predominantly African-American. The team said Chicago’s Hispanic and Latino communities were also more likely to be farther from trauma care than those living in white communities. The Hispanic and Latino disparity was not present in New York or Los Angeles.”Even though we had a sense that this was a racially divided issue, the data confirmed that this was the case in a significant way. It was pretty startling,” said Monica Peek, MD, MPH, an associate professor of medicine and health disparities researcher who was the senior author on the paper.UChicago Medicine has provided pediatric trauma care at Comer Children’s Hospital since 1990, but previously ended its adult trauma program in 1988 before announcing it would resume the service in 2015 in response to community requests. The hospital built a new adult emergency department, which opened in late December 2017. Adult trauma services launched about five months later, following regulatory approval.The researchers said they hope their findings highlight the lingering impact of structural inequality in U.S. cities. They said planning for new trauma centers, which require a significant financial investment, should include an assessment of how a new facility can help address racial equity. Source:https://www.uchicagomedicine.org/forefront/trauma-articles/2019/march/race-and-trauma-desert-researchlast_img read more

Tagged: , , , , , , , .

Biologists analyze available methods of targeted drug delivery to malignant tumors

Posted on by

first_imgReviewed by James Ives, M.Psych. (Editor)Apr 9 2019A team of biologists from Sechenov First Moscow State Medical University and Lobachevsky University (Nizhny Novgorod) analyzed available methods of targeted drug delivery to malignant tumors. Individual approaches to cancer therapy limit the influence of drugs on healthy tissues and reduce side effects. The results of the study were published in the Cancers journal. The research was supported by a grant issued by the Ministry of Science and Higher Education .The difference between healthy tissue and a tumor lies in the structure of its vasculature and changes in metabolism. In tumors blood vessels are formed chaotically, have different shapes and diameters, and exhibit closed ends and protrusions. The structure of lymphatic vessels also changes. A tumor and its vasculature grow at different speed causing oxygen and nutrients deficiency. The structure of the tissue and its metabolism changes, as well as the profile of molecules on the surface of tumor cells, and the cancer progresses. Taking these facts into consideration, one can develop methods of target antitumor drugs delivery without affecting healthy cells and causing unnecessary side effects.Currently, there are three main ways of targeted drug-to-tumor delivery: passive targeting that takes into account the structure of the vessels; active targeting in which an antitumor drug binds with a molecular target; and cell-mediated targeting.Due to the peculiarities of tumor vessels, large molecules can enter them relatively easily and accumulate in the tumor tissue. This phenomenon is known as enhanced permeability and retention effect, and passive drug targeting is based on it. However, this delivery method doesn’t always guarantee a desired effect. To increase its efficiency, individual therapies are developed on the basis of tumor characteristics. For example, the size of an agent may be optimized accordingly.Related StoriesDon’t Miss the Blood-Brain Barrier Drug Delivery (B3DD) Summit this AugustNew class of cancer-killing agents shows promise in destroying cancer stem cellsCommon cold virus strain could be a breakthrough in bladder cancer treatmentActive targeting complements the passive method. It increases the accumulation of a drug in tumor and the time of its retention. In their earlier work the team presented a multifunctional complex that leads to a synergistic effect of combined chemo- and radiotherapy agents. The base of the complex is a luminescent nanoparticle that contains a radioactive isotope 90Y used in radionuclide therapy. On the surface there is a bound highly active fragment of exotoxin A obtained from Pseudomonas aeruginosa (PE40). The complex binds with a marker protein of cancer cells, and its toxic agents affect the tumor. This treatment method works because tumor cells have different metabolism and molecular profiles than the cells of healthy tissues.Certain types of cells are able to penetrate tumor tissues and therefore can also be used to deliver drugs. Cell-mediated targeting extends the washout period, controls the release of the drug, and reduces general toxicity and side effects. This method has its limitations, but it is also very promising.”Having a choice between various treatment methods that take into account molecular and structural characteristics of a tumor and being able to adjust drug administration regime means approaching the goals of personalized medicine,” said Irina Balalayeva, a Candidate of Biological Sciences, Dean of the Department of Biophysics of the Institute of Biology and Biomedicine at Lobachevsky University, and a senior research associate of the laboratory of nanotheranostics at the Institute of Molecular Medicine, Sechenov Moscow State Medical University.Understanding the processes of nutrients and metabolic products transportation within a tumor, the peculiarities of its structure, and its interaction with immune system cells can help increase the efficiency of antitumor drug delivery and cancer treatment.Source: https://www.sechenov.ru/eng/news/141366/last_img read more

Tagged: , , , , , , , .

Eccentric exercises could help fatigued dancers prevent injury improve jump performance

Posted on by

first_imgOur study suggests fatigued dancers may lack the strength to control their legs when absorbing the forces from the landing, affecting the technique and artistry of their jump as well as increase risk for injury. Targeted eccentric exercises could enable them to control their movements when they’re tired. This may help them consistently perform the jump in good form as well as reduce the risk of injury.”Danielle N. Jarvis, PhD, ATC, senior author of the study and assistant professor of kinesiology at California State University Northridge Researchers studied 17 professional ballet dancers who performed 10 sauté jumps before and after a protocol designed to mimic a ballet class or rehearsal. They used a 12-camera motion capture system and force plates to collect three-dimensional movement data while the dancers performed the jumps. The researchers determined that the dancers’ ankles flexed more deeply upon landing when they were fatigued (30.32 degrees) compared to before they were tired (28.88 degrees). Fatigue also lessened the peak landing forces, meaning the dancers landed softer. The force plates determined they landed with 1.72 times their body weight when fatigued, vs. 2.13 times their body weight before they were fatigued. The motion capture system showed that while the dancers achieved the same jump height, they did not point their toes as proficiently when fatigued.Related StoriesDoing more harm than good: Scientists uncover harmful effects of dietary supplementsResearchers identify new sarcoma familial risk gene’Text neck’ may be causing bone spurs in young peopleBased on their findings, the researchers surmise that eccentric exercises could help lengthen and strengthen the calf muscles, counteracting the effects of fatigue. Eccentric muscle contractions occur in the lowering phase of a traditional movement (e.g. lowering into a squat, or lowering the arms after a biceps curl), causing a muscle to lengthen rather than shorten. One such exercise involves standing on both toes and then lowering one foot in a very slow, controlled manner, rather than letting the heel come down quickly.”Athletic trainers can work with dancers to identify eccentric movements they can do to achieve better control and jump more effectively,” said Dr. Jarvis. “We believe that if dancers are better able to control – and not collapse into – the landing, they are more likely to use the proper technique and may be less likely to get injured.” Source:National Athletic Trainers’ Association (NATA) Reviewed by James Ives, M.Psych. (Editor)Jun 26 2019Exercises that lengthen leg muscles may help dancers counteract fatigue, preventing injury and allowing for a more perfected jump technique, suggests research being presented at the National Athletic Trainers’ Association (NATA) 70th Clinical Symposia & AT Expo.Researchers studied how well trained ballet dancers performed the classic sauté jump – a vertical jump with feet pointing down – before and after becoming fatigued by dancing. When tired, the dancers’ form suffered, both in air and on landing.Dance is a very physically demanding activity and injuries are common. However, there is limited research examining the biomechanics of dance movements and the effects of fatigue on dance performance and technique. The researchers sought to assess fatigue and resulting movement patterns to shed light on how athletic trainers can better work with dancers to prevent injuries.last_img read more

Tagged: , , , , , , , .

As road rage incidents rise exponentially call for legal definition punishments gets

Posted on by
Tagged: , , , , , .